The CLK3 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CLK3. This antibody recognizes Human, Mouse, and Rat antigen. The CLK3 Antibody has been validated for the following applications: ELISA, and Western Blot.
Description
Description: Phosphorylates serine-and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines.
Function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine-and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Post-translational Modifications: Autophosphorylates on all three types of residues.
Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily